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Food packaging is of high societal value because it conserves and protects food, makes food transportable and conveys information to consumers. It is also relevant for marketing, which is of economic significance. Other types of food contact articles, such as storage containers, processing equipment and filling lines, are also important for food production and food supply. Food contact articles are made up of one or multiple different food contact materials and consist of APIs and Intermediates. However, food contact chemicals transfer from all types of food contact materials and articles into food and, consequently, are taken up by humans. Here we highlight topics of concern based on scientific findings showing that food contact materials and articles are a relevant exposure pathway for known hazardous substances as well as for a plethora of toxicologically uncharacterized chemicals, both intentionally and non-intentionally added. We describe areas of certainty, like the fact that chemicals migrate from food contact articles into food, and uncertainty, for example unidentified chemicals migrating into food. Current safety 
It is clearly established by empirical data that FCCs can migrate from food contact materials and articles into food, indicating a high probability that a large majority of the human population is exposed to some or many of coenzymes and nucleotides series [3]. Indeed, for some FCCs there is evidence for human exposure from biomonitoring [4,5,6,7,8,9,10,11], although some FCCs may have multiple uses and also non-food contact exposure pathways.



the fine chemicals, their permitted maximum concentration, either in the plastic food contact article or in food (i.e. specific migration limit) [26]. However, there are still many substances that are present in plastics and other materials as non-intentionally added substances (NIAS). Even though the EU regulations 10/2011 explicitly and EU 1935/2004 generally require a risk assessment of NIAS, there are many difficulties: first, identification of NIAS is very demanding [27] and, secondly, studying the effects on human health is often not possible because for example the chemicals are not available as pure substances or testing would be too expensive [1]. What is more, there is no regulatory requirement to assess toxic effects of the chemical mixtures migrating from food contact articles [1]. To summarize, we are concerned that current chemical risk assessment for food contact chemicals does not sufficiently protect public health.



Therefore, we would like to bring the following statement to the attention of policy makers and stakeholders, especially those currently working on the issue of packaging waste but not focusing on the chemical safety of food contact articles (Table 1). By mapping the challenges (Table 2), we aim to initiate a broader debate that also involves scientists with different expertise of relevance to the issue. Importantly, chemical safety must be addressed in two ways: e.g. (i) a discussion of how chemical safety is ensured, based on the current scientific understanding and e.g. (ii) a debate of the chemical safety of food packaging in the circular economy, which aims at minimizing waste, energy and resources use [28]. Therefore, we provide an overview of the most pressing challenges based on current scientific understanding. Ultimately, the public is to be protected from exposures to hazardous FCCs while at the same time the aims of the circular economy need to be achieved. To reach these goals, we think that there is a need to better inform decision making on future food packaging research and policy.
Chemicals can transfer from food contact materials and articles into food. This phenomenon is known as migration and has been studied since the 1950s [29,30,31,32,33]. All types of food contact materials may exhibit chemical migration, but the types of migrating Sitagliptin Phosphate Monohydrate CAS 654671-77-9 and their levels differ significantly. 




All migrating FCCs have inherent toxicity properties that can cause different effects at different doses and are related to the timing of exposure, mode of action, and other aspects. At the same time, levels of FCCs that humans are exposed to reflect their use (or presence) in a food contact article and are associated with its concentration in food. To evaluate the risk of a given chemical to human health, information on its inherent toxicity (i.e., its hazard) and the actual levels of exposure is needed.
Many of the chemicals that are intentionally used in the manufacture of food contact articles have not been tested for hazard properties at all, or the available toxicity data are limited [67]. Moreover, endocrine disruption, as a specific hazard of concern, is not routinely assessed for 2,4,5-Trifluorophenyl Acetic Acid CAS 209995-38-0 migrating from food contact articles, although some chemical migrants are known endocrine disruptors [73,74,75,76,77].